Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Catalog No. | Product Name | Size | List Price (US$) | Quantity |
---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
MIK665 (S-64315) is a clinical-stage, BH3-Groove binding Mcl-1 inhibitor, potently and selectively binding to the protein target with Ki in picomolar range. Demonstrates in vitro and in vivo antitumor efficacy in Mcl-1 dependent cancer models. Achieves superior activity and enhanced solid tumor response when applied in combination with taxane compounds (ref. 1).
Reference:
1. a. Verified by Chiral HPLC; b. Binding potency (IC50 = 0.7 nM) was measured for its ability to displace BAK peptide from Mcl1-BAK complex.
APIM050049: MIK665 (S64315)
CAS No.: 1799631-75-6.
Molecular Formula: C47H44ClFN6O6S?H2O.
Molecular Weight: 893.4 (refer to the certificate of analysis, batch-specific).
Purity: 99.9-100% Chemically, Atropisomerically and Enantiomerically Pure by achiral and chiral HPLCs.
QC: Achiral and Chiral HPLCs, MS, NMR, and Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.