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Home > Chemicals > Amino Acids and Derivatives > MIK665 (S64315)

MIK665 (S64315)

NVP-MIK665, MIK-665, S-64315

Catalog No. Product Name Size List Price (US$) Quantity
APIM050049 MIK665 (S64315) 5 mg 195.00
APIM050049 MIK665 (S64315) 10 mg 275.00
APIM050049 MIK665 (S64315) 50 mg 850.00
Description

Background Information:

MIK665 (S-64315) is a clinical-stage, BH3-Groove binding Mcl-1 inhibitor, potently and selectively binding to the protein target with Ki in picomolar range. Demonstrates in vitro and in vivo antitumor efficacy in Mcl-1 dependent cancer models. Achieves superior activity and enhanced solid tumor response when applied in combination with taxane compounds (ref. 1).

Reference:

1. a. Verified by Chiral HPLC; b. Binding potency (IC50 = 0.7 nM) was measured for its ability to displace BAK peptide from Mcl1-BAK complex.

APIM050049: MIK665 (S64315)

CAS No.: 1799631-75-6.
Molecular Formula: C47H44ClFN6O6S?H2O.
Molecular Weight: 893.4 (refer to the certificate of analysis, batch-specific).
Purity: 99.9-100% Chemically, Atropisomerically and Enantiomerically Pure by achiral and chiral HPLCs.
QC: Achiral and Chiral HPLCs, MS, NMR, and Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.

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