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Background Information:
Selpercatinib (LOXO-292) is an orally available, potent and highly selective RET (Rearranged during Transfection) inhibitor, with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively. Displays robust in vitro and in vivo efficacies against cancers harboring abnormalities in RET kinase.
APIM050040: LOXO-292 (SELPERCATINIB)
CAS No.: 2152628-33-4.
Molecular Formula: C29H31N7O3 • 0.2H2O.
Molecular Weight: 529.2.
Purity: >99.5% by HPLC (at 214 and 254 nm).
QC: HPLC, NMR, and Quantitative Elemental analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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