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Background Information:
LHC-165 is an agonist (activator) of Toll-like Receptor 7 (TLR7), and an immuno-oncology modulator. TLR7 is a protein in the immune system that surveys and recognizes pathological malignance, and triggers the immune response by releasing infection-clearing cytokines if activated. It has demonstrated in mice that LHC-165 induced immune response, and reduced tumor growth, also showed signs of an abscopal effect. It is currently under evaluation in patients with advanced malignancies, either as a single agent or in combination with checkpoint inhibitor.
APIM050038: LHC-165
CAS No.: 1258595-14-0.
Molecular Formula: C29H32F2N3O7P.
Molecular Weight: 603.6 (refer to the Certificate of Analysis, batch-specific).
Purity: >99.5% Pure by HPLC.
QC: HPLC, MS, NMR, and Quantitative Elemental analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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