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Background Information:
JNJ-64619178 is a clinical-stage SAM-pocket binding (SAM Competitive) PRMT5 inhibitor with high selectivity and potency (PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions. Demonstrates tumor regression in a biomarker-driven human small cell lung cancer xenograft model (NCI-H1048) and prolongs tumor growth inhibition after dosing cessation.
APIM050036: JNJ-64619178
CAS No.: 2086772-26-9.
Molecular Formula: C22H23BrN6O2.
Molecular Weight: 483.4 (refer to Certificate of Analysis, batch-specific).
Purity: 99.5-100% chemically and stereomerically pure (by achiral and chiral HPLCs).
QC: Achiral and Chiral HPLCs, MS, 1H-, NOESY-, COSY-NMRs, and Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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