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Background Information:
Deltarasin is a novel small molecule inhibiting the KRAS-PDEδ interaction and thus impairing oncogenic KRAS signalling. Deltarasin selectively binds to the prenyl-binding pocket of PDEδ with nanomolar affinity (IC50 = 41 nM, binding to PDEδ in cell) [Ref 1].
Reference:
1. Ref 1. G. Zimmermann, et al., Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling, Nature 2013, 497 (7451), 638–642
APIM050032: Deltarasin
CAS No.: 1440898-82-7 (HCl salt) 1440898-61-2 (Free Base).
Molecular Formula: C40H37N5O?3.3 HCl?3H2O.
Molecular Weight: 778.1
Purity: >99.5% chem and optical purity (HPLC and Chiral HPLC).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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