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Background Information:
AZD-7648 is an orally available potent and selective next generation DNA-dependent protein kinase (DNA-PK) inhibitor (Enzymatic and Cellular IC50s = 0.6 nM, 91 nM, respectively ), highly selective against a panel of 397 other kinases, including closely-related Kinases such as ATM, ATR, and PI3Kα, β, δ, γ. Exhibits antitumor efficacy either as a monotherapy or in combination with either cytotoxic chemotherapies or novel Anti-Cancer agents.
APIM050019: AZD7648
CAS No.: 2230820-11-6.
Molecular Formula: C18H20N8O2.
Molecular Weight: 380.4.
Purity: >99.5% by HPLC (at 215 nm and 254 nm).
QC: HPLC-MS, NMR, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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