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Background Information:
AZD4205 (AZD-4205) is a potent, selective and ATP-competitive inhibitor of JAK1 with a Ki of 2.8 nM, highly selective against JAK2 (IC50 =13233 nM, >4000 fold selectivity) and JAK3 (IC50 >30000 nM, >10000 fold selectivity). Demonstrates potent inhibition of p-STAT3 in a cell based assay of JAK1 activity with an IC50 of 128 nM and excellent selectivity across the kinome. Exhibits excellent pharmacokinetics, and in vitro and in vivo antitumor efficacy (refs 1, 2), and is currently in clinical evaluation.
APIM050014: AZD4205
CAS No.: 2091134-68-6.
Molecular Formula: C25H31N9O2? 0.7H2O.
Molecular Weight: 502.2.
Purity: >99% chem and optically pure by achiral and chiral HPLCs.
QC: Achiral and Chiral HPLCs, MS, NMR and Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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