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The research grade tocilizumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Recombinant Humanized IgG1 Monoclonal Antibody.
Isotype: Human IgG1 kappa.
Source: The anti-human IL-6R monoclonal antibody tocilizumab biosimilar was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade tocilizumab biosimilar specifically binds to the human interleukin-6 receptor (IL-6R).
Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by tocilizumab.
Form of Antibody: 0.2 uM filtered solution, pH 6.5, no stabilizers or preservatives.
Endotoxin: <1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.
Shipping: The research grade tocilizumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Background
What is tocilizumab biosimilar research grade? Tocilizumab biosimilar uses the same protein sequences as the therapeutic antibody tocilizumab. Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. Interleukin 6 (IL-6) is a pro-inflammatory cytokine produced by cells including T-cells, B-cells, lymphocytes, monocytes, fibroblasts. IL-6 rapidly induces C-reactive protein, serum amyloid A, fibrinogen, haptoglobin, and α-1-antichymotrypsin while inhibiting production of fibronectin, albumin, and transferrin. IL-6 also induces antibody production, induces cytotoxic T-cell differentiation, and inhibits regulatory T-cell differentiation. Tocilizumab binds soluble and membrane bound IL-6 receptors, preventing IL-6 mediated inflammation.
Syd Labs also provides the following anti-IL antibody biosimilar proteins:
Pascolizumab Biosimilar, research grade, anti-human IL-4 monoclonal antibody
Sarilumab Biosimilar, research grade, anti-human IL-6/IL-6R monoclonal antibody
Secukinumab Biosimilar, research grade, anti-human IL-17/IL-17a monoclonal antibody
Briakinumab Biosimilar, research grade, anti-human IL-12/IL-23 monoclonal antibody
Ustekinumab Biosimilar, research grade, anti-human IL-12/IL-23 monoclonal antibody
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