My Cart [ 0 ]
Home > Chemicals > Amino Acids and Derivatives > BMS-599626

BMS-599626

AC480
Catalog No. Product Name Size List Price (US$) Quantity
APIM012172-P70057 (1S,4R)-4-Boc-Amino-Cyclopent-2-Enyl-Methanol 10 g 490.00
APIM012172-P70057 (1S,4R)-4-Boc-Amino-Cyclopent-2-Enyl-Methanol 100 g 1900.00
Description

Background Information:

BMS-599626 is an orally bioavailable, Potent and selective EGFR and ErbB2 inhibitor with IC50 values of 22 nM and 32 nM respectively, and inhibits HER4 with reduced potency (IC50 = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. It is an Antiproliferative agent in vitro and anti-tumorigenic agent in vivo.

Reference:

1. Wong, TM., et al., Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling, Clin Cancer Res. 2006 Oct 15;12 (20 Pt 1):6186-93.
2.Haluska, P., et al., HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924, Mol Cancer Ther. 2008 Sep, 7(9):2589-98.

APIM050117: BMS-599626

CAS No.: 714971-09-2.
Molecular Formula: C27H27FN8O3.
Molecular Weight: 530.6.
Purity: >99% chem and optical purity (HPLC and chiral HPLC).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

Related Links

Super savings and terrific tips sent to your email inbox:

See our Privacy Policy