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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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The manufacturing conditions of Xolair biosimilar from the CHO stable cell line need to be optimized by clients.
The cheapest research grade omalizumab biosimilar protein (1 mg for >$30) is also available.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Omalizumab (trade name Xolair, Roche/Genentech and Novartis) is a humanized antibody used to reduce sensitivity to inhaled or ingested allergens, especially in the control of moderate to severe allergic asthma which does not respond to high doses of corticosteroids.
Immunoglobulin E (IgE) found in mammals only exists as monomers consisting of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). In addition to immunity to parasites, IgE plays an essential role in type I hypersensitivity, which manifests various allergic diseases, and allergic conditions, such as anaphylactic reactions to certain drugs, bee stings, and antigen preparations used in specific desensitization immunotherapy.
Omalizumab specifically binds to free IgE in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Unlike an ordinary anti-IgE antibody, omalizumab does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells.
C020: Xolair Biosimilar Stable Cell Line (CHO)
The yield of Xolair biosimilar from the CHO stable cell line was above 3.0 g/L in a 3 liter manufacturing.
The Xolair biosimilar stable cell line alone can be transfered alone or together with the technology of process development and/or antibody purification.
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