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sRANKL Protein

Soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE, TNF-related activation-induced cytokine, OPGL, ODF

Catalog No. Product Name Size List Price (US$) Quantity
BP000173-CYT-334 Recombinant Human RANK Ligand Soluble 10 ug 160.00
BP000173-CYT-334 Recombinant Human RANK Ligand Soluble 1 mg 4680.00
Description

Introduction
RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

BP000173-CYT-334: Recombinant Human RANK Ligand Soluble

Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 176 amino acids and having a molecular mass of 20006 Dalton.
The activity as determined by its ability to induce a dose dependant stimulation of IL-8 production in human PBMCs, is 39-51 ug/ml.
Purity > 98%, by SDS-PAGE and RP-HPLC.
Formulation: The protein was lyophilized from a concentrated (1 ug/ml) solution containing 10 mM Na2PO4, pH-8.0.
Reconstitution: It is recommended to reconstitute the lyophilized sRANKL in sterile 18 M?-cm H2O at a concentration of 100 ug/ml, which can then be further diluted to other aqueous solutions.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Other sRANKL Proteins:
Recombinant Mouse RANK Ligand Soluble
Recombinant Human Soluble RANK Ligand, GST tag

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