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SPARC Antibody

Secreted Protein, Acidic and Rich in Cysteine
Catalog No. Product Name Size List Price (US$) Quantity
PA005171-MPR11 SPARC Polyclonal Antibody 100 ug 250.00
Description

Background

SPARC (secreted protein, acidic and rich in cysteine) is a matrix associated protein that elicits changes in cell shape, inhibits cell cycle progression, and influences the synthesis of extracellular matrix (ECM). It is also known as osteonectin (ON) or basement-membrane protein 40 (BM-40). SPARC contains two calcium binding sites; an N-terminal acidic region and a C-terminal extracellular calcium binding domain with two EF-hand motifs. SPARC is produced by fibroblasts, capillary endothelial cells, platelets and macrophages, especially in areas of tissue morphogenesis and remodeling. SPARC is abundantly expressed in bone, where it promotes osteoblast differentiation and inhibits adipogenesis.

PA005171-MPR11: SPARC Polyclonal Antibody

Rabbit Polyclonal Antibody.
Applications: Western blot 2-10 ug/ml, ELISA 0.1-1 ug/ml.
Reactivity: Human, mouse, rat (not tested for other species).
Immunogen: Recombinant full-length human SPARC expressed in human cells.
Form of Antibody: Lyophilized from a sterile filtered solution of phosphate-buffered saline (PBS).

Storage/Stability: Stable for 1 year at -20 degrees Celsius C and 3 months at 4 degrees Celsius . For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.

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