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Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Measuring an antibody’s affinity to the Fcγ receptors has become an integral part of biotherapeutics development. Syd Labs has established a standard human Fcγ receptor panel binding assay in a high throughput format using the BLI platform. This in vitro binding assay can also be used for quality control purposed in parallel with functional cell-based ADCC. Additionally, Syd Labs offers clients an FcRn binding assay to study pH-dependent interaction of antibody with the neonatal Fc-receptor (FcRn) in high throughput and easy to use format. The outcome of the study will enhance overall understanding of the antibody and demonstrate comparability in the development of biosimilars.
FcRγ binding assay and FcRn binding assay services
The panel is performed using Octet Red96 (ForteBio):
- his-tagged receptors are immobilized onto anti-His biosensors;
- the loaded biosensors are dipped into a dilution series of the antibody;
- the on- (Kon) and off-rates (Koff) are measured and the KD value is calculated.
Materials needed:
- 100 ug each of purified antibody.
Fast turnaround:
2-3 weeks.
Deliverable:
Study report.
FcRn Protein:
Recombinant Human FcRn Protein
Recomninant FcRL1 Protein
Fc ELISA Kits and Reagents:
Human Fc ELISA Kit
Mouse Fc ELISA Kit
Human Fc ELISA Reagent Kit
Mouse Fc ELISA Reagent Kit
Fc Protein:
Recombinant Human Fc Protein (IgG1)
Recombinant Human Fc Protein (IgG2)
Recombinant Human Fc Protein (IgG4)
Recombinant Mouse Fc Protein (IgG1)
Fcγ Protein:
Recombinant Human Fc gamma RIIA Protein
Recombinant Human Fc gamma RIIB/C Protein
Recombinant Human Fc gamma RIIIA Protein (F158)
Recombinant Human Fc gamma RIIIA Protein (V158)
Recombinant Human Fc gamma RIIIB Protein
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