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PAK1KD Enzyme

PAK1 Kinase Domain

Catalog No. Product Name Size List Price (US$) Quantity
BP001573-K0104 Recombinant Human PAK1 kinase domain Enzyme 10 ug 340.00
BP001573-K0104 Recombinant Human PAK1 kinase domain Enzyme 100 ug 2500.00
BP001573-K0104 Recombinant Human PAK1 kinase domain Enzyme 1 mg 8000.00
Description

Introduction

Human PAK1 kinase (UniProt: Q13153; NCBI: NM_002576) belongs to a family of p21-activated kinases. These serine/threonine kinases serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 kinase regulates cell motility and morphology.

BP001573-K0104: Recombinant Human PAK1 Kinase Domain (PAK1KD) Enzyme

Source: E. coli-derived.
Predicted molecular mass: 33,646 Da. PAK1KD is fully phosphorylated at T423 and partially phosphorylated at additional sites with measured mass of 33,728 (1P), 33,808 (2P), 33,889 (3P), and 33,968 (4P).
Specific activity: 32,638 pmoles/min/?g. Analysis of enzymatic activity was performed according to the Zlyte assay protocol (Invitrogen).
Formulation: 1 ug/ml in Storage Buffer of 25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10% glycerol, 5 mM DTT.
Applications: Enzymatic studies, inhibitor screen, and selectivity profiling; High concentration available for crystallization.

Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.

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