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Introduction
Interferon regulatory factor 2 is a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. IRF2 binds to the upstream regulatory region of type-1 IFN and IFN-inducible MHC class-1 genes (the interferon consensus sequence (ics) and represses those genes.
BP000090-CYT-534: Recombinant Human IRF2
Source: E. coli-derived.
A single, non-glycosylated, polypeptide chain containing 133 amino acids (1-113) with a His Tag of 20 aa, and having a molecular mass of 15 kDa.
Purity > 95%, by SDS-PAGE and RP-HPLC.
Formulation: 1 ug/ml in 20 mM Tris pH-8, 1 mM DTT and 10% Glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
IRF2 Antibodies:
IRF2 Polyclonal Antibody
IRF2 Polyclonal Antibody
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