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Conditions of optimal IL1F7 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Introduction
Human interleukin family 1, member 7 (IL1F7) belongs to the interleukin 1 cytokine family. There are 5 alternatively spliced transcript variants encoding distinct isoforms with distinct expression profiles. The longest IL-1F7 transcript, named IL1F7b or IL1F7 isoform 1, encodes a 218 aa residues proprotein and containing a 45 aa propeptide which is cleaved to produce a mature protein. IL1F7b binds to IL18 R/Fc with low affinity however it does not exert any IL18 agonistic or antagonistic effects. IL1F7b also binds IL18BP (interleukin 18 binding protein), which is an inhibitory binding protein of interleukin 18 (IL18), and afterward forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18.
BP000167-CYT-011: Recombinant Human Interleukin-1 Family Member 7 (IL1F7) Protein
Source: E. coli-derived.
A single, non-glycosylated, Polypeptide chain containing 167 amino acids (Lys27-Asp192) and having a molecular mass of 18.6 kDa.
N-terminal sequence analysis: Met-Lys-Asn-Leu-Asn.
As measured by its binding ability in a functional ELISA, immobilized IL1F7 at 1 ug/ml (100 ul/well) can bind rhIL-18 R/Fc Chimera with a linear range of 0.015-1 ug/ml.
Purity: > 95% by SDS-PAGE and RP-HPLC.
Formulation: IL1F7 was lyophilized after extensive dialysis against 20 mM Phosphate buffer, pH7.4.
Reconstitution: It is recommended to quick spin followed by reconstitution of IL1F7 in PBS to a concentration no less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other IL1F7 Protein:
Recombinant Human IL1F7 Protein
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