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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal FVII and FVIIa Proteins performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Background
Coagulation factor VII (FVII) which is a vitamin K-dependent factor essential for hemostasis. FVII circulates in the blood in a zymogen form, and is converted to an active form (FVIIa) by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor (FVIIa) then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa.
References:
1. Kenet G, et al., 1999, Lancet 354 (9193): 1879.
2. Roberts H, et al., 2004, Blood. 104 (13): 3858-64.
3. Mayer S, et al., 2005, N. Engl. J. Med. 352 (8): 777-85.
4. O'Connell K, et al., 2006, JAMA. 295 (3): 293-8.
BP000036-GD11: Recombinant Human FVIIa Protein
Source: 293 cell derived.
Ala61-Pro466, Accession# NP_000122.1
N-terminal sequence analysis: Ala
Predicted molecular mass: 47 kDa
SDS-PAGE: 42 kDa, reducing conditions
The potency per mg of recombinant human FVIIa protein was tested and found to be 50,000 Units/mg.
Endotoxin Level: <1.0 EU per 1 ug of the protein by the LAL method.
Purity > 95%, by SDS-PAGE under reducing conditions.
Formulation: a 0.2 mm filtered solution (0.2 mg/ml) of sodium chloride (2.3 ug/ml), calcium chloride dihydrate (1.5 ug/ml), glycylglycine (1.3 ug/ml), polysorbate 80 (0.1 ug/ml), mannitol (25 ug/ml), sucrose (10 ug/ml), methionine (0.5 ug/ml), and histidine (1.6 ug/ml). pH. 6.0
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month if stored at 2°C to 8°C under sterile conditions.
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