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Fc (IgG2) Protein

Human Fc protein (IgG2), Human IgG2 Fc region
Catalog No. Product Name Size List Price (US$) Quantity
BP4092 Recombinant Human Fc Protein (IgG2) 1 mg 1800.00


Human Fc (IgG2) is the tail region of an immunoglobulin G2 (IgG2) that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. The ~230 amino acid fragment generally exists as a dimer, although under reducing conditions, it exists as a monomer. It is the basis of prolonged pharmacokinetics of antibodies and is commonly used as a fusion to extend half-life of fusion proteins. IgG2 has a shorter hinge than IgG1, with 12 amino acid residues and four disulfide bridges at the Fab base. The hinge region of IgG2 also lacks a glycine residue, which along with its shortness almost completely prevents rotation and restricts lateral movement of the Fabs.

BP4092: Recombinant Human Fc protein (IgG2)

The recombinant human IgG2 Fc protein was produced in HEK 293 cells and purified by protein A.
Purity: >95% by SDS-PAGE under reducing conditions
Endotoxin Level: Less than 1 EU/ug of protein as determined by LAL method.
Formulation: 0.2 µM filtered solution of 100 mM HEPES, 0.2% sodium acetate, pH 6.

Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month from date of receipt, 2 to 8°C as supplied.
3 months from date of receipt, -20°C to -70°C as supplied.

Other Recombinant IgG Fc Proteins:
Recombinant Human Fc Protein (IgG1)
Recombinant Human Fc Protein (IgG4)
Recombinant Mouse Fc Protein (IgG1)

Recombinant IgG Reference Antibodies:
Recombinant Human IgG1 Reference Antibody
Recombinant Human IgG2 Reference Antibody
Recombinant Human IgG4-S228P Reference Antibody
Recombinant Mouse IgG1 Reference Antibody
Recombinant Mouse IgG2a Reference Antibody
Recombinant Mouse IgG2b Reference Antibody

Fc ELISA Kits and Reagents:
Human Fc ELISA Kit
Mouse Fc ELISA Kit
Human Fc ELISA Reagent Kit
Mouse Fc ELISA Reagent Kit

Protein A, Resin, Columns, and ELISA Kits:
Recombinant Protein A
Protein A Affinity Resin
Pre-packed Protein A Column
Protein A ELISA Kit

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