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Services from custom cell line construction, cell culture, to cell assays.
    10 Cell Biology Services
  • Small to large scale production of monoclonal antibodies and recombinant proteins using mammalian cell culture of hybridoma, CHO, NSO, and HEK-293 cells.

  • Syd Labs provides not only stable cell line generation services for protein and antibody production but also cell culture services for small to large scales of previously developed stable cell lines expressing proteins or antibodies. If needed, Syd Labs also provide the process development service for cell culture of stable cell lines and the protein and antibody purification services.

  • - Any gene;
    - Any host cell, including primary cell;
    - Highly efficient and precise.

    Fast turnaround:

    Knock-out cell line generation: 16-19 weeks.
    Knock-in cell line generation: 20-24 weeks.

  • Experienced scientists working on antibody and cell line development services for decades. >90% success rate of stable cell line generation.

    Stable cell lines developed with our proprietary recombinant antibody expression system with multiple selectable markers is very productive in expressing target proteins.

    Fast turnaround:

    Basic service: 7-8 weeks.
    Premium service: 12-14 weeks.
    Pool cells: 6 weeks.

  • Experienced scientists working on antigen and antibody production, antibody engineering, lentivirus, and cell line development services for decades. >90% success rate of stable cell line generation.

    Fast turnaround:

    Antigen (peptide or protein) production: 3-6 weeks.
    Mouse monoclonal antibody production: 20-24 weeks.
    Screening phage or yeast libraries for fully human antibodies: 8-12 weeks.
    Sequencing hybrioma antibody: 1-3 weeks.
    Chimeric antibody production: 3-4 weeks.
    Antibody humanization: 8-10 weeks.
    Construction of CAR cassette, lentivirus packaging and production: 4-5 weeks.
    T-cell activation, transduction, and CAR T-cell expansion: 4-5 weeks.
    Confirmation of CAR expression, IFN-gamma ELISA, and cytotoxicity assay of transduced and expanded T-cells: 2 weeks.

  • While the success rate of stable cell line generation is highly dependent on the target genes and Syd Labs can not guarantee 100% success rate, our in-house data show a success rate greater than 90%.

    Fast turnaround of stable cell line development: 6-7 weeks.

    We have a lot of experience in dealing with difficult-to-express proteins.

  • Biologics production stable cell line development services utilize advanced technology platforms to generate cell lines expressing the target gene at very high levels for the manufacturing of recombinant proteins and antibodies.

    - Performed under GLP; manufactured product may be used in FDA Nonclinical Laboratory Studies.
    - Parental cell line is cGMP banked with certification.
    - Set licensing fee arrangement for commercial production license.
    - Cell lineage history of the cell line and testing details facilitate IND filing.

  • One-stop sequence optimization, gene synthesis, and DNA subcloning services.
    Various bacterial expression vectors developed by ourselves or our partners.

    Fast turnaround: 6-7 weeks.

    We have a lot of experience in dealing with difficult-to-express proteins.
    While the success rate of stable cell line generation is highly dependent on the target genes and Syd Labs can not guarantee 100% success rate, our in-house data show a success rate greater than 90%.

  • - Any gene;
    - Any host cell, including primary cell;
    - Significantly improved efficiency of changing protein expression level compared to non-viral DNA transfection methods.

    Fast turnaround:

    Clonal stable cell line generation: 12-14 weeks.
    Cell pool generation: 8-10 weeks.

  • Experienced scientists working on protein engineering, expression, and purification, and cell line development services for decades. >90% success rate of stable cell line generation.

    Stable cell lines developed with our proprietary protein expression system with multiple selectable markers is very productive in expressing target proteins.

    Fast turnaround:

    1 week for synthesizing a gene for expressing the target protein.
    1 week for molecular construction of the gene.
    5-6 weeks for generation of suspension CHO stable cell lines expressing the target protein.
    5-6 weeks for additional services included in the premium package.

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