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Conditions of optimal MCP 2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Introduction
Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2). The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.
BP000276-CHM-355: Recombinant Mouse C-C Motif Chemokine 8 (CCL8) Protein
Source: E. coli-derived.
A non-glycosylated, Polypeptide chain containing 74 amino acids and having a molecular mass of 8507 Dalton.
Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100 ug/ml corresponding to a Specific Activity of 10,000-100,000 IU/mg.
Purity: > 97% by SDS-PAGE and RP-HPLC.
Formulation: Lyophilized from a 0.2 um filtered concentrated (1.0 ug/ml) solution in 20 mM PB, pH 7.4, 150 mM NaCl.
Reconstitution: It is recommended to reconstitute the lyophilized CCL8in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other CCL8 Proteins:
Recombinant Human CCL8 Protein
Recombinant Human CCL8 Protein
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