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Conditions of optimal Cbfa2t2 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
PA000290-030814B06: Cbfa2t2 (MTGR1) Monoclonal Antibody
Rat Monoclonal Antibody.
Specificity/Sensitivity: Anti-mouse Cbfa2t2 (MTGR1).
Applications: Western blotting: starting from 1:1000, dilution range 1:250-1:2500.
Reactivity: Mouse.
Immunogen: MTGR1 peptide couple with BSA.
Purification: purified from culture supernatant using a protein G column.
Form of Antibody: 0.5 ug/ml in PBS containing 0.1% sodium azide as a preservative.
Clone No: KT42.
Isotype: Rat IgG2c.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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